Home Metabolism Factor Xa inhibitor Edoxaban For research use only.

Edoxaban

Synonyms: DU-176b, Savaysa

Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.

Edoxaban Chemical Structure

Edoxaban Chemical Structure

CAS: 480449-70-5

Selleck's Edoxaban has been cited by 4 publications

Purity & Quality Control

Batch: S442901 DMSO] 10 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.78%
99.78

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Biological Activity

Description Edoxaban (DU-176b, Savaysa), an antithrombotic agent, is a selective, potent and orally active inhibitor of factor Xa (FXa) with Ki of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively.
Targets
Factor Xa [1]
(Cell-free assay)		 Prothrombinase [1]
(Cell-free assay)
0.561 nM(Ki) 2.98 nM(Ki)
In vitro
In vitro

The dual split protein (DSP) assay using Calu-3 cells is performed in the presence of various anticoagulants, including edoxaban.[2]
Cell Research Cell lines Calu-3 cells
Concentrations --
Incubation Time --
Method

For the DSP assay using Calu-3 or H3255 cells, target cells were seeded in 384-well plates (2 × 104 cells/50 μL) one day before the assay. Two hours before the DSP assay, cells were treated with 6 μM EnduRen. One microliter of each protease inhibitor or anticoagulant dissolved in DMSO was added to the 384-well plates with 9 μL of culture medium. Next, 40 μL of single cell suspension (effector cells) was added to the wells using a Multidrop dispenser.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05339672 Recruiting Drug-drug Interaction Radboud University Medical Center|Astellas Pharma Inc July 1 2024 --
NCT06149533 Not yet recruiting Thrombosis Venous|Cancer|Catheter Complications Cancer Institute and Hospital Chinese Academy of Medical Sciences November 30 2023 Phase 3
NCT05869591 Not yet recruiting Liver Cirrhosis Centre Hospitalier Universitaire Vaudois October 2023 Phase 2
NCT05804747 Recruiting Atrial Fibrillation Daiichi Sankyo Inc.|Daiichi Sankyo Korea Co. Ltd. February 16 2023 --
NCT05122455 Recruiting SCAD|AMI University of Sao Paulo|Daiichi Sankyo Inc. September 14 2021 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 548.06 Formula

C24H30ClN7O4S
CAS No. 480449-70-5 SDF --
Smiles CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(Cl)C=C4)C(=O)N(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 10 mg/mL ( (18.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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