Home Metabolism Factor Xa inhibitor Edoxaban tosylate Monohydrate For research use only.

Edoxaban tosylate Monohydrate

Synonyms: DU-176b

Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

Edoxaban tosylate Monohydrate Chemical Structure

Edoxaban tosylate Monohydrate Chemical Structure

CAS: 1229194-11-9

Selleck's Edoxaban tosylate Monohydrate has been cited by 6 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

Other Factor Xa Products

Related compound libraries

Choose Selective Factor Xa Inhibitors

Biological Activity

Description Edoxaban (DU-176b) is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
Targets
Factor Xa [1]
(Cell-free assay)
0.561 nM(Ki)
In vitro
In vitro In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. [1]
In Vivo
In vivo Oral administration of Edoxaban produces potent anti-Xa activity and high drug concentration in plasma in rats and monkeys. In vivo, Edoxaban dose-dependently inhibits thrombus formation in rat and rabbit thrombosis models. [1]
Animal Research Animal Models Venous stasis thrombosis model in rats and rabbits
Dosages 0.3–3 mg/kg (Rabbit); 0.5–12.5 mg/kg (Rat)
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05339672 Recruiting Drug-drug Interaction Radboud University Medical Center|Astellas Pharma Inc July 1 2024 --
NCT06149533 Not yet recruiting Thrombosis Venous|Cancer|Catheter Complications Cancer Institute and Hospital Chinese Academy of Medical Sciences November 30 2023 Phase 3
NCT05869591 Not yet recruiting Liver Cirrhosis Centre Hospitalier Universitaire Vaudois October 2023 Phase 2
NCT05804747 Recruiting Atrial Fibrillation Daiichi Sankyo Inc.|Daiichi Sankyo Korea Co. Ltd. February 16 2023 --
NCT05122455 Recruiting SCAD|AMI University of Sao Paulo|Daiichi Sankyo Inc. September 14 2021 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 738.27 Formula

C24H30ClN7O4S.C7H8O3S.H2O
CAS No. 1229194-11-9 SDF Download Edoxaban tosylate Monohydrate SDF
Smiles CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O
Storage (From the date of receipt)

In vitro
Batch:


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Edoxaban tosylate Monohydrate | Edoxaban tosylate Monohydrate supplier | purchase Edoxaban tosylate Monohydrate | Edoxaban tosylate Monohydrate cost | Edoxaban tosylate Monohydrate manufacturer | order Edoxaban tosylate Monohydrate | Edoxaban tosylate Monohydrate distributor