Home Metabolism Glucosylceramide Synthase inhibitor Eliglustat hemitartrate For research use only.

Eliglustat hemitartrate

Synonyms: Genz-112638, Eliglustat tartrate, Cerdelga

Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.

Eliglustat hemitartrate Chemical Structure

Eliglustat hemitartrate Chemical Structure

CAS: 928659-70-5

Selleck's Eliglustat hemitartrate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.89%
99.89

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Biological Activity

Description Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.
Targets
Glucosylceramide Synthase [1]
(Cell-free assay)
24 nM
In vitro
In vitro

When treated gaucher disease neuronal progenitor cells (NPCs) with the GlcCer synthase inhibitors Eliglustat and the brain‐penetrant Ibiglustat, there are significant reductions in both, GlcCer and GlcSph levels in the mutant NPCs.[2]
Cell Research Cell lines gaucher disease neuronal progenitor cells
Concentrations 2 μM
Incubation Time 5 days
Method

For GlcCer synthase inhibition, NPCs were treated with a final concentration of 2 μM Eliglustat, Ibiglustat, or GZ667161, for 5 days.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00891202 Completed Gaucher Disease Type 1 Genzyme a Sanofi Company|Sanofi November 2009 Phase 3

Chemical lnformation & Solubility

Molecular Weight 959.17 Formula

C50H78N4O14
CAS No. 928659-70-5 SDF --
Smiles CCCCCCCC(=O)NC(CN1CCCC1)C(O)C2=CC3=C(OCCO3)C=C2.CCCCCCCC(=O)NC(CN4CCCC4)C(O)C5=CC6=C(OCCO6)C=C5.OC(C(O)C(O)=O)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (104.25 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 10 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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