Home Neuronal Signaling Histamine Receptor antagonist Emedastine For research use only.

Emedastine

Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).

Emedastine Chemical Structure

Emedastine Chemical Structure

CAS: 87233-61-2

Purity & Quality Control

Batch: Purity: 99.34%
99.34

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Biological Activity

Description Emedastine is a potent, high affinity histamine H1-receptor-selective antagonist with Ki of 1.3 ±0.1 nM for H1-receptors while considerably weaker at H2- (K1 = 49,067 ± 11,113 nM) and H3-receptors (Ki = 12,430 ± 1,282 nM).
Targets
H1 receptor [1]
(Cell-free assay)
1.3 nM(Ki)
In vitro
In vitro Emedastine is capable of potently inhibiting histamine-induced cytokine release as well as the chemotaxis of eosinophils, thereby influencing factors contributing to the inhibition of the signs and symptoms of allergic diseases[2].
In Vivo
In vivo In human, the half-life of emedastine, when administered as slow release capsules is of about 6±7 h[2].

Chemical lnformation & Solubility

Molecular Weight 302.41 Formula

C17H26N4O
CAS No. 87233-61-2 SDF --
Density 1.15 g/mL
Smiles CCOCCN1C2=CC=CC=C2N=C1N3CCCN(CC3)C
Storage (From the date of receipt) 2 years -20°C liquid

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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