Home Metabolism Retinoid Receptor agonist Etretinate For research use only.

Etretinate

Synonyms: Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359

Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.

Etretinate Chemical Structure

Etretinate Chemical Structure

CAS: 54350-48-0

Selleck's Etretinate has been cited by 1 publication

Purity & Quality Control

Batch: S469901 DMSO] 70 mg/mL] false] Ethanol] 70 mg/mL] false] Water] Insoluble] false Purity: 99.06%
99.06

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Biological Activity

Description Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Targets
RAR [1]
In Vivo
In vivo

There is a significant decrease in mean dermal thickness (P < 0.05) and changes in collagen bundles in the etretinate-treated mice group for a 28-day period compared to control groups. TUNEL assay shows that the density of TUNEL-positive cells in the dermis of etretinate-treated mice for a 14-day period is significantly increased (P < 0.05). The ratio of procollagen α 1 (I) chain to β actin mRNA from etretinate-treated mice for a 1-day period decreased significantly compared to that of the control mice, but the ratio from etretinatetreated mice for a 14-day period increased significantly (P < 0.05)[2]. Etretinate reduces dermal thickness, and suppresses the appearance of skin lesions by inducting apoptosis and perhaps regulation of cytokine expression in MRL/lpr mice[3].
Animal Research Animal Models BLM-induced sclerotic skin mice
Dosages 10 mg/kg
Administration oral administration
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04582383 Recruiting Acne University of Pennsylvania March 30 2022 Phase 4
NCT04018144 Unknown status Periodontitis Tokat Gaziosmanpasa University August 1 2019 --
NCT04020146 Completed Periodontitis|Periimplantitis Tokat Gaziosmanpasa University January 10 2018 --
NCT02847533 Unknown status Depression Centre Hospitalier Universitaire de Besancon September 2016 Not Applicable
NCT02620813 Completed Acne Vulgaris University of California Davis October 2015 Early Phase 1

Chemical lnformation & Solubility

Molecular Weight 354.48 Formula

C23H30O3
CAS No. 54350-48-0 SDF Download Etretinate SDF
Smiles CCOC(=O)C=C(C)C=CC=C(C)C=CC1=C(C(=C(C=C1C)OC)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 70 mg/mL ( (197.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 70 mg/mL

Water : Insoluble


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