Home Neuronal Signaling Histamine Receptor antagonist Famotidine For research use only.

Famotidine

Synonyms: MK208

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Famotidine Chemical Structure

Famotidine Chemical Structure

CAS: 76824-35-6

Selleck's Famotidine has been cited by 3 publications

Purity & Quality Control

Batch: S207801 DMSO] 67 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.48%
99.48

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Biological Activity

Description Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
Targets
H2 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06054464 Recruiting Healthy Volunteers PMV Pharmaceuticals Inc September 19 2023 Phase 1
NCT04941755 Completed Healthy Participants Bristol-Myers Squibb June 25 2021 Phase 1
NCT04614974 Active not recruiting Laryngomalacia|Gastro Esophageal Reflux Reema Padia|University of Pittsburgh November 18 2020 Phase 1|Phase 2
NCT04179071 Completed Solid Tumours AstraZeneca|Parexel December 13 2019 Phase 1

Chemical lnformation & Solubility

Molecular Weight 337.45 Formula

C8H15N7O2S3
CAS No. 76824-35-6 SDF Download Famotidine SDF
Smiles C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (198.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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