Home Immunology & Inflammation COX inhibitor Firocoxib (ML 1785713) For research use only.

Firocoxib (ML 1785713)

Synonyms: ML 1785713

Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood.

Firocoxib (ML 1785713) Chemical Structure

Firocoxib (ML 1785713) Chemical Structure

CAS: 189954-96-9

Purity & Quality Control

Batch: E050001 DMSO] 67 mg/mL] false] Ethanol] 3 mg/mL] false] Water] Insoluble] false Purity: 99.92%
99.92

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Biological Activity

Description Firocoxib (ML 1785713) is a cyclooxygenase (COX)-2 inhibitor and a nonsteroidal anti-inflammatory drug. In vitro firocoxib inhibits COX-1 and COX-2 with an IC50 of 7.5 mM and 0.13 mM respectively in feline blood.
Targets
COX-2 [1]
(in feline blood)
130 μM
In Vivo
In vivo

Firocoxib is a potent, selective COX-2 inhibitor used in cats, which is effective in attenuating febrile responses in cats when administered 14 hours before LPS challenge.[1]
Animal Research Animal Models Domestic shorthair cats
Dosages 1, 3 mg/kg for LPS challenge study 1; 0.75, 1.5 mg/kg for LPS challenge study 2
Administration o.g.

Chemical lnformation & Solubility

Molecular Weight 336.4 Formula

C17H20O5S
CAS No. 189954-96-9 SDF --
Smiles CC1(C)OC(=O)C(=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3CC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 67 mg/mL ( (199.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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