Home Endocrinology & Hormones Glucocorticoid Receptor agonist Flumethasone For research use only.

Flumethasone

Synonyms: RS-2177, NSC-54702,Flumetasone

Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.

Flumethasone Chemical Structure

Flumethasone Chemical Structure

CAS: 2135-17-3

Selleck's Flumethasone has been cited by 2 publications

Purity & Quality Control

Batch: S408801 DMSO] 82 mg/mL] false] Ethanol] 6 mg/mL] false] Water] Insoluble] false Purity: 99.79%
99.79

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Biological Activity

Description Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
Targets
glucocorticoid receptor [1]
In Vivo
In vivo

Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. [1] Flumethasone combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. [2] Flumethasone (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. Flumethasone (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. [3] The Flumethasone level in the treated animals is generally above the detection limit although, in most cases, the concentration of Flumethasone is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. Flumethasone is also detectable in the accompanying urine samples in calves. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. [4]

Chemical lnformation & Solubility

Molecular Weight 410.45 Formula

C22H28F2O5
CAS No. 2135-17-3 SDF Download Flumethasone SDF
Smiles CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (199.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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