Home Endocrinology & Hormones Glucocorticoid Receptor agonist Fluticasone propionate For research use only.

Fluticasone propionate

Synonyms: CCI-187881

Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.

Fluticasone propionate Chemical Structure

Fluticasone propionate Chemical Structure

CAS: 80474-14-2

Selleck's Fluticasone propionate has been cited by 4 publications

Purity & Quality Control

Batch: S199201 DMSO] 100 mg/mL] false] Ethanol] 5 mg/mL] false] Water] Insoluble] false Purity: 99.97%
99.97

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Biological Activity

Description Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. [1] Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. [2] Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. [3]
In Vivo
In vivo Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02630121 Recruiting Sleep Apnea|Chronic Nasal Congestion University of South Florida April 2023 Phase 4
NCT05608681 Recruiting Eosinophilic Esophagitis Eupraxia Pharmaceuticals Inc. March 31 2023 Phase 1
NCT05085587 Unknown status Bioequivalence|Asthma Respirent Pharmaceuticals Co Ltd.|Becro Ltd. October 1 2021 Phase 1

Chemical lnformation & Solubility

Molecular Weight 500.57 Formula

C25H31F3O5S
CAS No. 80474-14-2 SDF Download Fluticasone propionate SDF
Smiles CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (199.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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