Home Metabolism Factor Xa inhibitor Fondaparinux Sodium (Org 31540) For research use only.

Fondaparinux Sodium (Org 31540)

Synonyms: Natural heparin pentasaccharide Sodium, Fondaparin sodium, SR-90107A

Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa.

Fondaparinux Sodium (Org 31540) Chemical Structure

Fondaparinux Sodium (Org 31540) Chemical Structure

CAS: 114870-03-0

Purity & Quality Control

Batch: Purity: >97%
97

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Biological Activity

Description Fondaparinux Sodium (Org 31540, Natural heparin pentasaccharide, Fondaparin, SR-90107A) is a synthetic glucopyranoside with antithrombotic activity. It selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin; a synthetic inhibitor of Factor Xa.
Targets
Factor Xa [1]
In vitro
In vitro Fondaparinux is a synthetic pentasaccharide that selectively inhibits factor Xa (FXa) in the coagulation cascade. Fondaparinux has been shown to inhibit the TF-FVIIa complex and FIXa in vitro[1].
Cell Research Cell lines U937 cells
Concentrations 0-100 μg/ml
Incubation Time 30 min
Method

Fondaparinux was diluted in PBS to a total volume of 50 μL and added to the wells. Labeled U937 cells (50 μL) were then added and incubated at room temperature for 30 min. Finally, the wells were washed three times with PBS and cells were lyzed using 2% Triton X-100 in 0.1 mol/L Tris-HCl pH 9.5.
In Vivo
In vivo Fondaparinux reduces kidney I/R injury primarily by inhibiting the recruitment of neutrophil. It dramatically reduced fibrin deposition in the kidney[1]. Fondaparinux can promote the stability of atherosclerotic lesions in apolipoprotein E-deficient mice, possibly through inhibiting expression of the inflammatory mediators in plaque and reduced synthesis of MMP-9 and MMP-13[2].
Animal Research Animal Models Murine model of kidney I/R (background: C57BL/6)
Dosages 5-10 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00436787 Completed Venous Thrombosis|Pulmonary Embolism University of Pittsburgh|GlaxoSmithKline February 2007 Phase 2

Chemical lnformation & Solubility

Molecular Weight 1728.08 Formula

C31H43N3O49S8.10Na
CAS No. 114870-03-0 SDF Download Fondaparinux Sodium (Org 31540) SDF
Smiles COC1C(C(C(C(O1)COS(=O)(=O)[O-])OC2C(C(C(C(O2)C(=O)[O-])OC3C(C(C(C(O3)COS(=O)(=O)[O-])OC4C(C(C(C(O4)C(=O)[O-])OC5C(C(C(C(O5)COS(=O)(=O)[O-])O)O)NS(=O)(=O)[O-])O)O)OS(=O)(=O)[O-])NS(=O)(=O)[O-])O)OS(=O)(=O)[O-])O)NS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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