Home Proteases Serine Protease inhibitor - COVID-19 inhibitor FOY251 For research use only.

FOY251

FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.

FOY251 Chemical Structure

FOY251 Chemical Structure

CAS: 71079-09-9

Purity & Quality Control

Batch: S351101 DMSO] 82 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.00%
99.00

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Biological Activity

Description FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. FOY251 inhibits SARS-CoV-2 infection.
Targets
synthetic serine protease [1]
In vitro
In vitro

FOY-251 decreases equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibits the protease activity of prostasin in vitro.[1]
Cell Research Cell lines Mouse cortical collecting duct cell line (M-1 cells)
Concentrations 0.01–10 μM
Incubation Time 24 h
Method

M-1 cells were cultured on semi-permeable membrane, serum deprived for 24 h, and treated with 0.01-1 μM camostat mesilate or 0.01-10 μM FOY-251 from the apical side. After 24 h incubation, transepithelial voltage (Vte) and resistance (Rte) were measured with a volt ohm meter. Ieq was determined as the ratio of Vte to Rte and was normalized by dividing Ieq by the surface area (113 mm2 ) of active membrane.
In Vivo
In vivo

FOY-251 increases the circulating levels of FGF21 of transcription and plasma are maintained with induction of liver integrated stress response (ISR) transcription target genes up to 1 wk of treatment in both ob/ob and lean mice, also increases plasma FGF21 levels when dosed to DIO mice.[3]
Animal Research Animal Models Male ob/ob mice, lean and diet-induced obese (DIO) C57BL/6 mice
Dosages 0.8 mg/g food
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04451083 Completed Healthy Volunteers Ono Pharmaceutical Co. Ltd July 1 2020 Phase 1
NCT02693093 Completed Chronic Pancreatitis Kangen Pharmaceuticals Inc February 24 2016 Phase 1|Phase 2

Chemical lnformation & Solubility

Molecular Weight 409.41 Formula

C17H19N3O7S
CAS No. 71079-09-9 SDF --
Smiles C[S](O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC2=CC=C(CC(O)=O)C=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 82 mg/mL ( (200.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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