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Glycerol phenylbutyrate

Name: Glycerol phenylbutyrate
Brand: Selleck Chemicals
SKU: S6981

Synonyms: GT4P, HPN-100M, Ravicti

Catalog No.S6981 Purity: 99.51%

Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.

Glycerol phenylbutyrate Chemical Structure

CAS: 611168-24-2

Purity & Quality Control

Batch: S698101 Purity: 99.51%

99.51

Related compound libraries

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Biological Activity

Description

Targets

σ2 receptor ^[2]

8.02(pKi)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05983588	Recruiting	Corticobasal Syndrome (CBS)	Technical University of Munich	December 12 2023	Phase 2
NCT05019417	Unknown status	Monocarboxylate Transporter 8 Deficiency	Kaplan Medical Center\|Weizmann Institute of Science	June 30 2021	Phase 2\|Phase 3
NCT02323100	Terminated	Cystic Fibrosis	National Jewish Health\|University of Alabama at Birmingham\|Children''s Hospital of Philadelphia\|Johns Hopkins University\|Horizon Pharma Ireland Ltd. Dublin Ireland	December 2 2018	Phase 1\|Phase 2
NCT02246218	Completed	Urea Cycle Disorder	Horizon Therapeutics LLC\|Horizon Pharma Ireland Ltd. Dublin Ireland	December 31 2014	Phase 4

References

Chemical lnformation & Solubility

Molecular Weight	530.65	Formula	C₃₃H₃₈O₆
CAS No.	611168-24-2	SDF	--
Density	1.13 g/mL
Smiles	O=C(CCCC1=CC=CC=C1)OCC(COC(=O)CCCC2=CC=CC=C2)OC(=O)CCCC3=CC=CC=C3
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

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