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Granisetron

Name: Granisetron
Brand: Selleck Chemicals
SKU: S5052
Rating: 5 (1 reviews)

Synonyms: Sancuso, Kevatril, Granisetronum, Sustol

Catalog No.S5052 Purity: 98%

Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.

Granisetron Chemical Structure

CAS: 109889-09-0

Selleck's Granisetron has been cited by 1 publication

Purity & Quality Control

Batch: S505201 DMSO] 11 mg/mL] false] ] ] false] ] ] false Purity: 98%

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Biological Activity

Description

Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.

Targets

5HT-3 ^[1]

In vitro
In vitro	In radioligand binding studies on rat brain membranes, BRL 43694 had little or no affinity for 5-HT1A, 5-HT1B , 5-HT2 or for many other binding sites^[1].

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05434663	Active not recruiting	Chemotherapy-Induced Nausea and Vomiting (CINV)	Heron Therapeutics	July 6 2022	Phase 4
NCT04918862	Completed	1mg Vs 3 mg of Granisetron	Cairo University\|Mohamed Yousry Mohamed\|Tamer Fayez Safan\|Tamer Mohamed Khair\|Mohamed Ahmed A. M.D.\|Islam Mohamed Sayed	January 8 2021	Phase 3

References

[1] Sanger GJ, et al. Eur J Pharmacol. 1989, 159(2):113-24.

Chemical lnformation & Solubility

Molecular Weight	312.41	Formula	C₁₈H₂₄N₄O
CAS No.	109889-09-0	SDF	--
Smiles	CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 11 mg/mL ( (35.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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