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Halcinonide

Name: Halcinonide
Brand: Selleck Chemicals
SKU: S4098

Synonyms: SQ-18566

Catalog No.S4098 Purity: 99.93%

Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.

Halcinonide Chemical Structure

CAS: 3093-35-4

Purity & Quality Control

Batch: Purity: 99.93%

99.93

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Biological Activity

Description	Halcinonide(SQ-18566) is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.

In vitro
In vitro	Halcinonide is used topically in the treatment of certain skin conditions. Halcinonide interacts with steroid cytoplasmic receptors to induce antiinflammatory actions.^[1]

In Vivo
In vivo	Halcinonide cream (0.1%) results in a significant decrease in mean adhesion scores on both postoperative days 3 and 7 in the damaged surface of the cecum of Wistar rats, and the adhesion incidence is 43.3% for the therapy groups and 100% for controls. Halcinonide cream (0.1%) reduces the total numbers of intraperitoneal leukocytes from 270 millions to 120.73 millions on day 3 in the Wistar rats. ^[1]

References

[1] Zhang YD, et al. Am J Surg, 2002, 184(1), 74-77.

Chemical lnformation & Solubility

Molecular Weight	454.96	Formula	C₂₄H₃₂ClFO₅
CAS No.	3093-35-4	SDF	Download Halcinonide SDF
Smiles	CC1(OC2CC3C4CCC5=CC(=O)CCC5(C4(C(CC3(C2(O1)C(=O)CCl)C)O)F)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 91 mg/mL ( (200.01 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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