Home Neuronal Signaling AChR antagonist Homatropine Methylbromide For research use only.

Homatropine Methylbromide

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Homatropine Methylbromide Chemical Structure

Homatropine Methylbromide Chemical Structure

CAS: 80-49-9

Selleck's Homatropine Methylbromide has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.79%
99.79

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Biological Activity

Description Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
Targets
mAChR (WKY-E) [1] mAChR (SHR-E) [1]
162.5 nM 170.3 nM
In vitro
In vitro Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. [2] Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses. [3]
In Vivo
In vivo Homatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. [4] Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure. [5]
Animal Research Animal Models Sprague-Dawley rats
Dosages 20 mg/kg
Administration Intramuscular (IM) injections

Chemical lnformation & Solubility

Molecular Weight 370.28 Formula

C17H24NO3.Br
CAS No. 80-49-9 SDF --
Smiles C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 74 mg/mL ( (199.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 74 mg/mL

Ethanol : 74 mg/mL


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In vivo
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