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Hydroquinone

Synonyms: Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ

Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ) is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Hydroquinone Chemical Structure

Hydroquinone Chemical Structure

CAS: 123-31-9

Selleck's Hydroquinone has been cited by 2 publications

Purity & Quality Control

Batch: S458001 DMSO] 22 mg/mL] false] Water] 22 mg/mL] false] Ethanol] 22 mg/mL] false Purity: 99.93%
99.93

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Biological Activity

Description Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ) is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
In vitro
In vitro At 50 µM HQ(Hydroquinone), R-28 cells show a significant decrease in cell viability compared with the dimethyl sulfoxide (DMSO)-treated controls. At the 100–500 µM concentrations, all three cell lines show significant cell death (P <0.001). In the ARPE-19, R-28, and HMVEC cultures, the caspase-3/7 activities are not increased at any of the HQ concentration. Neuroretinal R-28 cells are more sensitive to HQ than the ARPE-19 and HMVEC cultures[1].
Cell Research Cell lines ARPE-19, R-28, and HMVEC
Concentrations 500 µM, 200 µM, 100 µM, 50 µM
Incubation Time 24 h
Method

ARPE-19, R-28, and HMVEC are treated for 24 h with four different concentrations of HQ (500 µM, 200 µM, 100 µM, 50 µM). Cell viability, caspase-3/7 activation, DNA laddering patterns, and lactate dehydrogenase (LDH) levels are analyzed.
In Vivo
In vivo In vivo exposure of rats to HQ results in changes of immune response mirrored by impairing allergic lung response to ovalbumin, an antigen unrelated to HQ. HQ exposure impairs the expression of CD45R and CD6 co-stimulatory molecules on activated spleen lymphocytes and diminishes the levels of OA(ovalbumin)-anaphylactic antibodies and the subsequent mast cell degranulation in sensitized rats challenged with OA[2].
Animal Research Animal Models Male Wistar rats
Dosages 50 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06193499 Not yet recruiting Osteoarthritis Thumb Karolinska Institutet January 17 2024 Not Applicable
NCT06173531 Enrolling by invitation Hyperphagia in Prader-Willi Syndrome ACADIA Pharmaceuticals Inc. November 27 2023 Phase 3

Chemical lnformation & Solubility

Molecular Weight 110.11 Formula

C6H6O2
CAS No. 123-31-9 SDF Download Hydroquinone SDF
Smiles C1=CC(=CC=C1O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 22 mg/mL ( (199.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 22 mg/mL

Ethanol : 22 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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