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Icatibant Acetate

Name: Icatibant Acetate
Brand: Selleck Chemicals
SKU: S5695

Synonyms: HOE-140 acetate

Catalog No.S5695 Purity: 99.90%

Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Icatibant Acetate Chemical Structure

CAS: 138614-30-9

Purity & Quality Control

Batch: Purity: 99.90%

99.90

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Biological Activity

Description

Icatibant Acetate(HOE-140 acetate) acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema.

Targets

bradykinin B2 receptor ^[1]

In vitro
In vitro	Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, resulting in a longer half-life than bradykinin which it antagonizes^[1].

In Vivo
In vivo	Icatibant exhibits efficacy in bradykinin-mediated angioedema attacks, and induces rapid symptom relief^[1].

References

[1] Charignon D, et al. Expert Opin Pharmacother. 2012, 13(15):2233-47.

Chemical lnformation & Solubility

Molecular Weight	1364.57	Formula	C₆₁H₉₃N₁₉O₁₅S
CAS No.	138614-30-9	SDF	--
Smiles	C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
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In vivo
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