Home Microbiology β-lactamase inhibitor Imipenem For research use only.

Imipenem

Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.

Imipenem Chemical Structure

Imipenem Chemical Structure

CAS: 74431-23-5

Purity & Quality Control

Batch: Purity: 99.79%
99.79

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Choose Selective β-lactamase Inhibitors

Biological Activity

Description Imipenem acts as an inhibitor of AmpC β-lactamase and is an antibiotic useful for the treatment of a number of bacterial infections.
Targets
AmpC β-lactamase [1]
In vitro
In vitro Imipenem, a β-lactam antibiotic, binds to penicillin binding protein 2 with the highest affinity and produces rounded cells. The binding of imipenem causes cells to lyse quickly and thereby to release less free endotoxin[1].
In Vivo
In vivo Imipenem has a very short half-life[1]. Imipenem has antimycobacterial activity both in a mouse model and in humans at high risk for failure of treatment for MDR (multiple-drug-resistant) tuberculosis[2].
Animal Research Animal Models BALB/c mice
Dosages 50, 75, and 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05561764 Recruiting Cystic Fibrosis|Pneumonia Bacterial Hartford Hospital|Merck Sharp & Dohme LLC|Q2 Solutions|Connecticut Children''s Medical Center|St. Christopher''s Hospital for Children|University of Texas Southwestern Medical Center|University of Pittsburgh Medical Center|Indiana University Health Methodist Hospital|James Whitcomb Riley Hospital for Children January 3 2023 Phase 4
NCT05146154 Enrolling by invitation Obesity|Critical Illness University of Illinois at Chicago|Merck Sharp & Dohme LLC January 1 2023 Phase 4
NCT05516433 Recruiting Enterobacteriaceae Infections Fondation Hôpital Saint-Joseph January 23 2023 --
NCT05285046 Enrolling by invitation Bacterial Infections|Antibiotic Resistant Infection D''Or Institute for Research and Education April 1 2022 --
NCT04802863 Completed Bacterial Infections Evopoint Biosciences Inc. March 25 2021 Phase 1
NCT04801043 Completed Bacterial Infections Evopoint Biosciences Inc. March 2 2021 Phase 1

Chemical lnformation & Solubility

Molecular Weight 317.36 Formula

C12H17N3O4S.H2O
CAS No. 74431-23-5 SDF Download Imipenem SDF
Smiles CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O
Storage (From the date of receipt)

In vitro
Batch:

Water : 63 mg/mL

DMSO : 1 mg/mL ( (3.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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