Home Immunology & Inflammation NOS chemical L-Arginine HCl (L-Arg) For research use only.

L-Arginine HCl (L-Arg)

Synonyms: (S)-(+)-Arginine hydrochloride

L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

L-Arginine HCl (L-Arg) Chemical Structure

L-Arginine HCl (L-Arg) Chemical Structure

CAS: 1119-34-2

Selleck's L-Arginine HCl (L-Arg) has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.33%
99.33

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Biological Activity

Description L-Arginine(L-Arg,(S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
In vitro
In vitro

L-Arginine (0.3 mM, 30 minutes) supplementation do not induce any significant increases in the peak NO concentration at low level of native LDL. However, at native LDL concentrations from 60-130 mg cholesterol/dL, NO concentration is 2 times higher than before L-Arginine treatment in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment results in a significant increase of NO production in n-LDL–treated cells as well as in oxidized -LDL–treated cells in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) does not increase O2- concentration at low nativeLDL concentrations but reduce O2- production by 50% when incubate with n-LDL at concentrations >40 mg cholesterol/dL in bovine aortic endothelial cells. L-Arginine (0.3 mM, 30 minutes) pretreatment completely abolishes O2- production at every oxidized LDL dosage in bovine aortic endothelial cells. [1]
In Vivo
In vivo

L-Arginine (4 mg/kg/min for 1 hour) treatment decreases superoxide generation by cNOS while increasing NO accumulation in rabbit limb during ischemia/reperfusion. L-Arginine (4 mg/kg/min for 1 hour) prevents microvessel constriction in the reperfused muscle despite reduced but still apparent interstitial edema in rabbit limb. L-Arginine (4 mg/kg/min for 1 hour) treatment results in a significant reduction of muscular reperfusion edema in rabbit limb. [2] L-Arginine (0.1 g/kg, oral) supplementation significantly reduces pulmonary artery systolic pressure by a mean of 15.2% after 5 days of therapy in patients with sickle cell disease. Both L-Arginine and ornithine concentrations increased significantly after 5 days of oral L-Arginine (0.1 g/kg) supplementation in patients with sickle cell disease. [3] L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. [4] L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06137833 Not yet recruiting Fatigue|Breast Cancer Pharmanutra S.p.a.|Latis S.r.l. November 27 2023 Not Applicable
NCT05934318 Not yet recruiting Pregnancy|Malaria|Nutrition|Placental Development|Preterm Birth|Fetal Growth Restriction Liverpool School of Tropical Medicine|Kenya Medical Research Institute|University of Toronto|Telethon Kids Institute September 30 2023 Not Applicable
NCT06025383 Recruiting Menopause|Hypertension Texas Tech University July 20 2023 Not Applicable
NCT06044194 Recruiting Heart Failure Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico|DAMOR Farmaceutici S.p.a. March 21 2023 Phase 3
NCT05298410 Completed Hypertension Limitless Research Inc.|KGK Science Inc. March 17 2022 Phase 2

Chemical lnformation & Solubility

Molecular Weight 210.66 Formula

C6H14N4O2.HCl
CAS No. 1119-34-2 SDF Download L-Arginine HCl (L-Arg) SDF
Smiles C(CC(C(=O)O)N)CN=C(N)N.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 42 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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