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L-Thyroxine (Levothyroxine)

Name: L-Thyroxine (Levothyroxine)
Brand: Selleck Chemicals
SKU: S2599

Synonyms: NSC 36397

Catalog No.S2599 Purity: 100%

L-Thyroxine (Levothyroxine) is a synthetic form of thyroxine and a hormone replacement drug.

L-Thyroxine (Levothyroxine) Chemical Structure

CAS: 51-48-9

Purity & Quality Control

Batch: Purity: 100%

100

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Biological Activity

Description	L-Thyroxine (Levothyroxine) is a synthetic form of thyroxine and a hormone replacement drug.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06096454	Not yet recruiting	Hypothyroidism\|Insulin Resistance	Assiut University	November 20 2023	Phase 4
NCT05918497	Active not recruiting	Different Regimens in Treatment of Hypothyroidism During Fasting in Ramadan	Sohag University	April 25 2023	--
NCT05646420	Recruiting	Autosomal Dominant Polycystic Kidney	Mario Negri Institute for Pharmacological Research	February 1 2023	Not Applicable
NCT05412979	Active not recruiting	Hypothyroidism	Sention Therapeutics LLC	April 29 2022	Phase 2
NCT06135948	Completed	L-thyroxine	Emirates Health Services (EHS)\|University of Sharjah	March 15 2022	Phase 4
NCT04712760	Unknown status	Congenital Hypothyroidism	Central Hospital Nancy France	February 22 2021	--

Chemical lnformation & Solubility

Molecular Weight	776.87	Formula	C₁₅H₁₁I₄NO₄
CAS No.	51-48-9	SDF	Download L-Thyroxine (Levothyroxine) SDF
Smiles	C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (128.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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