Home Endocrinology & Hormones GHSR inhibitor Lanreotide For research use only.

Lanreotide

Synonyms: Laromustine, Angiopeptin, BIM 23014, BIM 23014C, BM 23014, Dermopeptin, ITM-014, ITM-014T, Lanreotidum

Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, ITM-014, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.

Lanreotide Chemical Structure

Lanreotide Chemical Structure

CAS: 108736-35-2

Purity & Quality Control

Batch: Purity: 99.75%
99.75

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Biological Activity

Description

Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, ITM-014, Lanreotidum), an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.
Targets
growth hormone [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04649580 Completed Neuroendocrine Tumours (NET) Ipsen April 27 2021 --
NCT04003519 Withdrawn Acromegaly Ipsen April 2020 --
NCT03947762 Terminated Pancreatic Neuroendocrine Tumor Ipsen July 3 2019 --
NCT03012594 Completed Gastrointestinal Motility Disorder|Intestinal Disease Northwell Health|Ipsen May 11 2017 Phase 2
NCT03112694 Completed Neuroendocrine Tumors Ipsen April 4 2017 --

Chemical lnformation & Solubility

Molecular Weight 1096.32 Formula

C54H69N11O10S2
CAS No. 108736-35-2 SDF --
Smiles CC(C)C1NC(=O)C(CCCCN)NC(=O)C(CC2=C[NH]C3=C2C=CC=C3)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CSSCC(NC1=O)C(=O)NC(C(C)O)C(N)=O)NC(=O)C(N)CC5=CC6=CC=CC=C6C=C5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (91.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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