Home Microbiology CMV inhibitor Letermovir (AIC246) For research use only.

Letermovir (AIC246)

Synonyms: MK-8228

Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.

Letermovir (AIC246) Chemical Structure

Letermovir (AIC246) Chemical Structure

CAS: 917389-32-3

Selleck's Letermovir (AIC246) has been cited by 2 publications

Purity & Quality Control

Batch: S887301 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 99.87%
99.87

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Biological Activity

Description Letermovir (AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors.
In vitro
In vitro

AIC246 blocks viral replication without inhibiting the synthesis of progeny HCMV DNA or viral proteins. It is one of the most potent anti-HCMV agents reported to date, with a cell culture EC50 in the one-digit nanomolar range (∼5 nM) and a selectivity index exceeding 15,000[1].
In Vivo
In vivo

AIC246 treatment leads to a dose-dependent reduction of the HCMV titer in transplanted cells compared to that of the placebo-treated control group using the mouse xenograft model[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06118515 Not yet recruiting Congenital Cytomegalovirus Infection National Institute of Allergy and Infectious Diseases (NIAID) November 16 2023 Phase 1
NCT06057194 Not yet recruiting Infections Cytomegalovirus Maimónides Biomedical Research Institute of Córdoba|MERCK SHARP & DOHME DE ESPAÑA S.A. October 2023 Phase 2
NCT05446571 Recruiting Pregnant Women|CMV Infected Fetuses Assistance Publique - Hôpitaux de Paris October 20 2023 Phase 3
NCT06001320 Recruiting Kidney Transplant; Complications|CMV Virginia Commonwealth University|Merck Sharp & Dohme LLC September 25 2023 Early Phase 1
NCT05626530 Recruiting Cytomegalovirus Infections|Infection in Solid Organ Transplant Recipients|Neutropenia|Antiviral Toxicity Tufts Medical Center February 2 2023 Phase 4
NCT06021210 Recruiting CMV Infection|Hematopoietic Stem Cell Transplantation The First Affiliated Hospital of Soochow University July 7 2022 Phase 2

Chemical lnformation & Solubility

Molecular Weight 572.55 Formula

C29H28F4N4O4
CAS No. 917389-32-3 SDF --
Smiles COC1=C(C=C(C=C1)C(F)(F)F)N2C(C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (174.65 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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