Home Angiogenesis EGFR inhibitor Lidocaine hydrochloride For research use only.

Lidocaine hydrochloride

Synonyms: Lidocaine HCL, Lidothesin, Lignocaine hydrochloride, Xyloneural

Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

Lidocaine hydrochloride Chemical Structure

Lidocaine hydrochloride Chemical Structure

CAS: 73-78-9

Selleck's Lidocaine hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S466701 DMSO] 54 mg/mL] false] Water] 54 mg/mL] false] Ethanol] 54 mg/mL] false Purity: 99.86%
99.86

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Biological Activity

Description Lidocaine hydrochloride (Lidothesin, Lignocaine, Xyloneural) is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
Targets
EGFR [3]
In vitro
In vitro Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway[1]. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells[3].
Cell Research Cell lines Human Corneal Endothelial Cells
Concentrations 0.15625–10.0 g/l
Incubation Time 4-28 hr
Method Cells at logarithmic phase are treated with lidocaine hydrochloride at concentrations (w/v) from 10 to 0.15625 g/l in step dilutions. HCE cells without lidocaine treatment are used as controls. The morphology and growing status of the cells are monitored every 4 hr.
In Vivo
In vivo Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons[2].
Animal Research Animal Models Male Wistar rats
Dosages 1, 3, 10 mg/kg
Administration i.v.

Chemical lnformation & Solubility

Molecular Weight 270.8 Formula

C14H22N2O.HCl
CAS No. 73-78-9 SDF Download Lidocaine hydrochloride SDF
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.4 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 54 mg/mL

Ethanol : 54 mg/mL


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