Home Microbiology Fungal inhibitor Luliconazole For research use only.

Luliconazole

Synonyms: NND 502

Luliconazole(NND 502) is a broad-spectrum antifungal drug.

Luliconazole Chemical Structure

Luliconazole Chemical Structure

CAS: 187164-19-8

Purity & Quality Control

Batch: S425801 DMSO] 71 mg/mL] false] Ethanol] 5 mg/mL] false] Water] Insoluble] false Purity: 99.99%
99.99

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Biological Activity

Description Luliconazole(NND 502) is a broad-spectrum antifungal drug.
In vitro
In vitro

Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). [1] Luliconazole demonstrates greater potency against Trichophyton spp. (MIC range: [2]
In Vivo
In vivo

Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05110638 Active not recruiting Onychomycosis of Toenail SATO Pharmaceutical Co. Ltd. September 13 2021 Phase 1
NCT02767947 Completed Tinea Corporis Bausch Health Americas Inc. February 8 2016 Phase 4
NCT02767271 Completed Tinea Pedis|Tinea Cruris Bausch Health Americas Inc. December 2 2015 Phase 4
NCT02394340 Completed Tinea Pedis|Tinea Cruris Bausch & Lomb Incorporated|Bausch Health Americas Inc. February 3 2015 Phase 4

Chemical lnformation & Solubility

Molecular Weight 354.28 Formula

C14H9Cl2N3S2
CAS No. 187164-19-8 SDF Download Luliconazole SDF
Smiles C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (200.4 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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