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Resmetirom (MGL-3196)

Name: Resmetirom (MGL-3196)
Brand: Selleck Chemicals
SKU: S6663
Rating: 5 (2 reviews)

Synonyms: VIA-3196

Catalog No.S6663 Purity: 99.81%

Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.

Resmetirom (MGL-3196) Chemical Structure

CAS: 920509-32-6

Selleck's Resmetirom (MGL-3196) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.81%

99.81

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Biological Activity

Description

Targets

THR-β ^[1]
(Cell-free assay)

0.21μM(EC50)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04951219	Recruiting	Non-Alcoholic Fatty Liver Disease	Madrigal Pharmaceuticals Inc.	July 9 2021	Phase 3
NCT04197479	Completed	Non-Alcoholic Fatty Liver Disease	Madrigal Pharmaceuticals Inc.	December 16 2019	Phase 3
NCT04671069	Completed	Healthy	Madrigal Pharmaceuticals Inc.	July 26 2019	Phase 1
NCT03900429	Active not recruiting	NASH - Nonalcoholic Steatohepatitis	Madrigal Pharmaceuticals Inc.	March 28 2019	Phase 3
NCT04671056	Completed	Healthy	Madrigal Pharmaceuticals Inc.	November 9 2018	Phase 1
NCT03220165	Completed	Healthy	Madrigal Pharmaceuticals Inc.\|Worldwide Clinical Trials	August 6 2017	Phase 1

References

[1] Kelly MJ,et al.J Med Chem. 2014 May 22;57(10):3912-23.

Chemical lnformation & Solubility

Molecular Weight	435.22	Formula	C₁₇H₁₂Cl₂N₆O₄
CAS No.	920509-32-6	SDF	--
Smiles	CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 87 mg/mL ( (199.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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