Home Neuronal Signaling 5-HT Receptor antagonist Mirtazapine For research use only.

Mirtazapine

Synonyms: Org3770,6-Azamianserin

Mirtazapine (Org3770,6-Azamianserin) is an adrenergic and seroton receptor antagonist, used to treat depression.

Mirtazapine Chemical Structure

Mirtazapine Chemical Structure

CAS: 85650-52-8

Purity & Quality Control

Batch: S201601 DMSO] 53 mg/mL] false] Ethanol] 53 mg/mL] false] Water] Insoluble] false Purity: 99.99%
99.99

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Biological Activity

Description Mirtazapine (Org3770,6-Azamianserin) is an adrenergic and seroton receptor antagonist, used to treat depression.
Targets
5-HT [1]
In vitro
In vitro

Mirtazapine displays marked affinity for cloned, human alpha2A-adrenergic (AR) receptors at which it blocks noradrenaline (NA)-induced stimulation of guanosine-5'-O-(3-[35S]thio)-triphosphate ([35S]-GTPgammaS) binding. Mirtazapine shows high affinity for cloned, human serotonin (5-HT)2C receptors at which it abolishes 5-HT-induced phosphoinositide generation. Mirtazapine markedly elevates dialysate levels of NA and, in FCX, DA, whereas 5-HT is not affected.[1] Mirtazapine enhances the effectiveness of the electrical stimulation of the ascending 5-HT pathway by blocking both alpha-2 adrenergic auto- and heteroreceptors. Mirtazapine blocks the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. [2]
In Vivo
In vivo

Mirtazapine (10-250 mg/kg i.v.) enhances dose-dependently the firing activity of the 5-HT neurons in naive rats, but not in 6-hydroxydopamine-pretreated rats. [2] Mirtazapine (5 mg/kg/day, s.c., using osmotic minipumps) increases the spontaneous firing activity of locus coeruleus noradrenaline (NA) neurons in male Sprague-Dawley rats. Mirtazapine antagonizes both the enhancing effect of a low dose (10 mg/kg, i.v.) and the reducing effect of a high dose (100 mg/kg, i.v.) of the alpha 2-adrenoceptor agonist clonidine on the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of dorsal hippocampus CA3 pyramidal neurons. [3] Mirtazapine (5 mg/kg s.c.) only slightly affects DOPAC and homovanillic acid levels in the striatum, hardly affects 5-HT release in freely moving rats, but clearly increased 5-hydroxyindole acetic acid. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05452174 Enrolling by invitation Pregnancy|Severe Nausea and Vomiting|Hyperemesis Gravidarum Northwestern University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) June 13 2022 Phase 1|Phase 2
NCT04614584 Recruiting Methamphetamine Use Disorder|Drug Interaction|Cardiovascular Abnormalities San Francisco Department of Public Health|University of California Los Angeles July 12 2021 Phase 1
NCT03785691 Terminated Hyperemesis Gravidarum|Nausea Gravidarum|Vomiting of Pregnancy Nordsjaellands Hospital|Bispebjerg Hospital|Aarhus University Hospital|Herlev and Gentofte Hospital|Hvidovre University Hospital|Odense University Hospital|Rigshospitalet Denmark|Regionernes Medicinpulje|Kolding Sygehus March 1 2019 Phase 2
NCT03935685 Recruiting Glioma of Brain University of California Irvine February 26 2019 Phase 2

Chemical lnformation & Solubility

Molecular Weight 265.35 Formula

C17H19N3
CAS No. 85650-52-8 SDF Download Mirtazapine SDF
Smiles CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (199.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : Insoluble


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In vivo
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