Home GPCR & G Protein GPR agonist - Apoptosis related modulator - Autophagy modulator Monomethyl Fumarate For research use only.

Monomethyl Fumarate

Synonyms: MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate

Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Monomethyl Fumarate Chemical Structure

Monomethyl Fumarate Chemical Structure

CAS: 2756-87-8

Selleck's Monomethyl Fumarate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.59%
99.59

Other GPR Products

Related compound libraries

Choose Selective GPR Inhibitors

Biological Activity

Description Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.
Targets
GPR109A [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06066957 Not yet recruiting Cytomegalovirus Infections|Transplant-Related Disorder University of Pennsylvania|Merck Sharp & Dohme LLC January 1 2024 Phase 2
NCT05858970 Not yet recruiting Optical Biopsy|Colonic Dysplasia|Diagnostic Accuracy Fondazione Policlinico Universitario Agostino Gemelli IRCCS November 2023 --
NCT05538208 Not yet recruiting Lupus Nephritis Children''s Hospital Medical Center Cincinnati|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|Genentech Inc. August 2023 Phase 2
NCT04776473 Recruiting Intra-articular Fracture of the Mandibular Condyle Assistance Publique - Hôpitaux de Paris May 3 2023 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 130.10 Formula

C5H6O4
CAS No. 2756-87-8 SDF --
Smiles COC(=O)\C=C\C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 26 mg/mL ( (199.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 26 mg/mL

Water : 20 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Monomethyl Fumarate | Monomethyl Fumarate supplier | purchase Monomethyl Fumarate | Monomethyl Fumarate cost | Monomethyl Fumarate manufacturer | order Monomethyl Fumarate | Monomethyl Fumarate distributor