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Montelukast Sodium

Name: Montelukast Sodium
Brand: Selleck Chemicals
SKU: S4211
Rating: 5 (7 reviews)

Synonyms: MK0476

Catalog No.S4211 Purity: 99.86%

Montelukast Sodium selectively antagonizes leukotriene D₄ (LTD₄) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1. Montelukast improves macroautophagy but not the chaperone-mediated autophagy pathway. Solutions are unstable and should be fresh-prepared.

Montelukast Sodium Chemical Structure

CAS: 151767-02-1

Selleck's Montelukast Sodium has been cited by 7 publications

Purity & Quality Control

Batch: Purity: 99.86%

99.86

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Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
HEK293	Function assay	10 mins	Antagonist activity against CysLT1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pre-incubated for 10 mins before LTD4 addition by Fluo-4 AM dye based fluorimetric assay, IC50=0.31μM	26985325
HEK293	Function assay	10 mins	Antagonist activity against CysLT2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pre-incubated for 10 mins before LTD4 addition by Fluo-4 AM dye based fluorimetric assay, IC50=27μM	26985325
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Biological Activity

Description

Targets

CysLT1 ^[1]

In vitro
In vitro	Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation. ^[1]

In Vivo
In vivo	Montelukast (6 mg/kg, once per day for 20 d) significantly suppresses the increased eosinophils in BAL fluid and lung tissue, and increases IL-5 level in BAL fluid in OVA challenged mice. OVA challenge increases CysLT1 but decreases CysLT2 receptor mRNA expression. Montelukast inhibits the increased CysLT1 but not the reduces CysLT2 expression after OVA challenge. ^[2]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04351698	Recruiting	Anemia Sickle Cell\|Sleep-Disordered Breathing	Great Ormond Street Hospital for Children NHS Foundation Trust\|Guy''s and St Thomas'' NHS Foundation Trust\|University College London Hospitals\|North Middlesex University Hospital\|King''s College Hospital NHS Trust\|The Whittington Hospital NHS Trust	October 16 2023	Phase 2\|Phase 3
NCT05651750	Unknown status	To Evaluate PSQ as Clinical Tool in the Decision Between Medical and Surgical Treatment for Adenotonsillar Hypertrophy\|To Determine Clinical Response to Montelukast or Nasal Steroids Based on PSQ Results	Assaf-Harofeh Medical Center	November 15 2022	Phase 4
NCT05064631	Recruiting	Respiratory Tract Infections\|Pediatric Respiratory Diseases\|Wheezing	Queen Mary University of London\|Queensland University of Technology	January 12 2022	Phase 2
NCT05710081	Recruiting	Wheezing\|Bronchiolitis\|Asthma in Children	Barts & The London NHS Trust\|University of Aberdeen\|University of Edinburgh\|King''s College London\|University of Southampton\|Menzies School of Health Research	November 30 2021	Phase 3

References

Chemical lnformation & Solubility

Molecular Weight	608.17	Formula	C₃₅H₃₆ClNO₃S.Na
CAS No.	151767-02-1	SDF	Download Montelukast Sodium SDF
Smiles	CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)[O-])O.[Na+]
Storage (From the date of receipt)	3 years -20°C powder	Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 100 mg/mL ( (164.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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