Home Microbiology β-lactamase inhibitor Nafcillin Sodium For research use only.

Nafcillin Sodium

Synonyms: CL 8491

Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.

Nafcillin Sodium Chemical Structure

Nafcillin Sodium Chemical Structure

CAS: 7177-50-6

Purity & Quality Control

Batch: S404201 DMSO] 91 mg/mL] false] Water] 91 mg/mL] false] Ethanol] 20 mg/mL] false Purity: 99.10%
99.10

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Biological Activity

Description Nafcillin sodium (CL 8491) reversibly inhibits β-lactamase with Kd of 33 mM.
Targets
β-lactamase [1]
33 mM(Kd)
In vitro
In vitro Nafcillin sodium inactivates β-lactamase through forming a covalent acyl-enzyme intermediate with β-lactamase via Ser-70. At concentrations above 80 mM, Nafcillin displays complete inhibition of β-lactamase within 200 s. Upon removal of the excess Nafcillin, the inhibited enzyme can be re-activated completely, with a rate constant of 2×10-3/s (25 ℃). [1] Nafcillin sodium is activity against penicillin-resistant staphylococci. The minimal concentration necessary for antistaphylococcic activity in vitro ranges from 0.2 μg/mL to 2 μg/mL. [2]

Chemical lnformation & Solubility

Molecular Weight 454.47 Formula

C21H21N2O5S.H2O.Na
CAS No. 7177-50-6 SDF Download Nafcillin Sodium SDF
Smiles CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 91 mg/mL ( (200.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 91 mg/mL

Ethanol : 20 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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