Home Neuronal Signaling COX inhibitor - GABA Receptor inhibitor Niflumic acid For research use only.

Niflumic acid

Synonyms: Nifluril

Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.

Niflumic acid Chemical Structure

Niflumic acid Chemical Structure

CAS: 4394-00-7

Selleck's Niflumic acid has been cited by 1 publication

Purity & Quality Control

Batch: S301801 DMSO] 56 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.92%
99.92

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Biological Activity

Description Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
Targets
COX-2 [1] GABA receptor [1]
In vitro
In vitro

Niflumic acid inhibits Ca2+-activated Cl- channels with inhibition constant of 17 mM. Niflumic acid also inhibits ICl(Ca) elicited by bath application of Ca2+ to oocytes permeabilized using the Ca2+ ionophore A23187, demonstrating that the inhibition of ICl(Ca) is due to a direct interaction with the Cl- channel, rather than by interference with Ca2+ entry through voltage-dependent Ca2+ channels. [1] Niflumic acid blocks Ca2+-activated non-selective cation channels in inside-out patches from the basolateral membrane of rat exocrine pancreatic cells with IC50 of 50 μM. [2] Niflumic acid dose-dependently and reversibly activates large conductance calcium-activated K+ (KCa) channels. [3] Niflumic acid produces a concentration-dependent inhibition of spontaneous transient inward current (STIC, calcium-activated chloride current) amplitude. Niflumic acid inhibits noradrenaline- and caffeine-evoked IO(Ca) with an ICM50 of 6.6 μM, i.e.is less potent against evoked currents compared to spontaneous currents. Niflumic acid voltage-dependently inhibits spontaneous transient inward current (STIC) amplitude with IC50 of 2.3 μM and 1.1 μM at -50 and +50 mV respectively. [4] Niflumic acid inhibits not only IL-13-induced goblet cell hyperplasia but also airway hyperresponsiveness and eosinophilic infiltration. Niflumic suppresses the eotaxin levels in bronchoalveolar lavage fluids and overexpression of the MUC5AC gene, a marker of goblet cell hyperplasia, in the lung after IL-13 instillation. Niflumic acid suppresses JAK2 activation, STAT6 activation, and eotaxin expression in epithelial cells. [5]

Chemical lnformation & Solubility

Molecular Weight 282.22 Formula

C13H9F3N2O2
CAS No. 4394-00-7 SDF Download Niflumic acid SDF
Smiles C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (198.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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