Home Angiogenesis Bcr-Abl inhibitor - Autophagy activator - AMPK activator Nilotinib hydrochloride monohydrate For research use only.

Nilotinib hydrochloride monohydrate

Synonyms: Tasigna, AMN-107 hydrochloride monohydrate

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Nilotinib hydrochloride monohydrate Chemical Structure

Nilotinib hydrochloride monohydrate Chemical Structure

CAS: 923288-90-8

Selleck's Nilotinib hydrochloride monohydrate has been cited by 12 publications

Purity & Quality Control

Batch: S489501 DMSO] 100 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.98%
99.98

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Biological Activity

Description Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
Targets
AMPK [1] Bcr-Abl [1]
(in Murine myeloid progenitor cells)
30 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05185947 Recruiting Gynecologic Cancer|Gynecologic Neoplasms|Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 13 2022 Phase 2
NCT04326933 Active not recruiting Patients Diagnosed as Chronic Meyloid Leukemia Assiut University January 1 2020 --
NCT04002674 Recruiting Dementia With Lewy Bodies Georgetown University|National Institutes of Health (NIH) July 1 2019 Phase 2
NCT03942094 Recruiting Chronic Myeloid Leukemia Chronic Phase|Nilotinib Shenzhen Second People''s Hospital|Zhongshan People''s Hospital Guangdong China|Affiliated Hospital of Guangdong Medical University|Huazhong University of Science and Technology Union Shenzhen Hospital|Dongguan People''s Hospital|Longgang District Central Hospital of Shenzhen June 1 2019 Phase 3

Chemical lnformation & Solubility

Molecular Weight 583.99 Formula

C28H25ClF3N7O2
CAS No. 923288-90-8 SDF --
Smiles O.Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C)C=C3)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (171.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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