Home Protein Tyrosine Kinase VEGFR inhibitor - FGFR inhibitor - PDGFR inhibitor Nintedanib Ethanesulfonate Salt For research use only.

Nintedanib Ethanesulfonate Salt

Synonyms: Intedanib, BIBF 1120

Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.

Nintedanib Ethanesulfonate Salt Chemical Structure

Nintedanib Ethanesulfonate Salt Chemical Structure

CAS: 656247-18-6

Selleck's Nintedanib Ethanesulfonate Salt has been cited by 16 publications

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
Targets
VEGFR2 [1]
(Cell-free assay)		 VEGFR3 [1]
(Cell-free assay)		 VEGFR1 [1]
(Cell-free assay)		 FGFR2 [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 Click to View More Targets
13 nM 13 nM 34 nM 37 nM 59 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05676112 Withdrawn Pulmonary Fibrosis Boehringer Ingelheim|China-Japan Friendship Hospital December 29 2023 --
NCT06070610 Completed Healthy Boehringer Ingelheim November 8 2023 Phase 1
NCT05755308 Not yet recruiting Idiopathic Pulmonary Fibrosis Fondazione Policlinico Universitario Agostino Gemelli IRCCS October 2023 Not Applicable
NCT06071013 Not yet recruiting Non-small Cell Lung Cancer|EGFR Gene Mutation|EGFR-TKI Resistant Mutation China Medical University Hospital September 28 2023 Phase 1|Phase 2
NCT05817240 Completed Idiopathic Pulmonary Fibrosis Endeavor Biomedicines Inc. May 3 2023 Phase 1

Chemical lnformation & Solubility

Molecular Weight 649.76 Formula

C31H33N5O4.C2H6O3S
CAS No. 656247-18-6 SDF --
Smiles CCS(=O)(=O)O.CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (153.9 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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