Home GPCR & G Protein Adrenergic Receptor agonist Noradrenaline bitartrate monohydrate For research use only.

Noradrenaline bitartrate monohydrate

Synonyms: Levophed

Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

Noradrenaline bitartrate monohydrate Chemical Structure

Noradrenaline bitartrate monohydrate Chemical Structure

CAS: 108341-18-0

Purity & Quality Control

Batch: Purity: 99.94%
99.94

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Biological Activity

Description Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
Targets
alpha-adrenergic receptor [1]
In vitro
In vitro Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations’ and would, through an enhancement of ‘bottom-up’ information processing at the expense of irrelevant ‘top-down’ expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06068764 Recruiting Coronary Artery Disease Hartford Hospital December 5 2023 Phase 4
NCT06116305 Not yet recruiting Acute on Chronic Liver Failure Institute of Liver and Biliary Sciences India November 5 2023 --
NCT06013345 Recruiting Atrial Fibrillation Charles University Czech Republic October 25 2023 Phase 3
NCT05990933 Not yet recruiting Inflammatory Response|Diabetes type1|Hypoglycemia Cees Tack|Radboud University Medical Center September 2023 Not Applicable
NCT04046861 Not yet recruiting Hyperlactatemia|Cardiac Disease|Bypass Complication|Valve Disease Heart|Vitamin C University Medical Centre Maribor February 1 2023 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 337.28 Formula

C8H11NO3.C4H6O6.H2O
CAS No. 108341-18-0 SDF Download Noradrenaline bitartrate monohydrate SDF
Smiles C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (198.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 67 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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