Home Neuronal Signaling Adrenergic Receptor agonist (−)-Norepinephrine For research use only.

(−)-Norepinephrine

Synonyms: Arterenol, Levarterenol, L-Noradrenaline

(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

(−)-Norepinephrine Chemical Structure

(−)-Norepinephrine Chemical Structure

CAS: 51-41-2

Selleck's (−)-Norepinephrine has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.64%
99.64

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Biological Activity

Description (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
Targets
α2A adrenoceptor [1]
(CHO-C10 cells)		 α1 adrenoceptor [1]
(cell-based assay)		 β1 adrenoceptor [1]
(cell-based assay)
56 nM(Ki) 330 nM(Ki) 740 nM(Ki)
In vitro
In vitro

(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2]
In Vivo
In vivo

Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3]

Chemical lnformation & Solubility

Molecular Weight 169.18 Formula

C8H11NO3
CAS No. 51-41-2 SDF --
Storage (From the date of receipt) 3 years -20°C(in the dark) powder
1 year -80°C(in the dark) in solvent

In vitro
Batch:

DMSO : 3 mg/mL ( (17.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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