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Norgestrel

Name: Norgestrel
Brand: Selleck Chemicals
SKU: S5709

Synonyms: WY-3707, SH-70850, SH-850, FH 122-A

Catalog No.S5709 Purity: 99.91%

Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.

Norgestrel Chemical Structure

CAS: 6533-00-2

Purity & Quality Control

Batch: S570901 DMSO] 62 mg/mL] false] Ethanol] 21 mg/mL] false] Water] Insoluble] false Purity: 99.91%

99.91

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Biological Activity

Description	Norgestrel (WY-3707, SH-70850, SH-850, FH 122-A) is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. It also has strong neuroprotective activity.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05896384	Recruiting	Healthy	Boehringer Ingelheim	December 7 2023	Phase 1
NCT06048536	Recruiting	Contraception	Viatris Inc.	March 7 2023	Phase 2
NCT04131517	Terminated	Healthy Female Participants	UCB Biopharma SRL\|UCB Pharma	October 23 2019	Phase 1
NCT03745144	Completed	Relapsing Multiple Sclerosis (RMS)	Merck KGaA Darmstadt Germany	January 17 2019	Phase 1

Chemical lnformation & Solubility

Molecular Weight	312.45	Formula	C₂₁H₂₈O₂
CAS No.	6533-00-2	SDF	--
Smiles	CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 62 mg/mL ( (198.43 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 21 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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