Home Others Hydrotropic Agents chemical NOTA For research use only.

NOTA

NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid is a bifunctional chelating agent which acts as the framework to construct PET imaging tools. It is also used for probe design and signal amplification via the multivalent effect and also has potential applications as diagnostic gallium radiopharmaceuticals.

NOTA Chemical Structure

NOTA Chemical Structure

CAS: 56491-86-2

Purity & Quality Control

Batch: S692301 DMSO] 61 mg/mL] false] Water] 50 mg/mL] false] Ethanol] 2 mg/mL] false Purity: >97%
97

Related compound libraries

Choose Selective Hydrotropic Agents Inhibitors

Biological Activity

Description NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid is a bifunctional chelating agent which acts as the framework to construct PET imaging tools. It is also used for probe design and signal amplification via the multivalent effect and also has potential applications as diagnostic gallium radiopharmaceuticals.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06005116 Recruiting Bladder Cancer RenJi Hospital September 15 2023 Not Applicable
NCT06165874 Recruiting Non-small Cell Lung Cancer Huashan Hospital March 12 2023 Not Applicable
NCT05490264 Recruiting Solid Tumor|Positron-Emission Tomography(PET) SmartNuclide Biopharma|The First Affiliated Hospital of Soochow University October 18 2022 Early Phase 1
NCT06147362 Recruiting Cancer Karolinska University Hospital|Stockholm South General Hospital|Uppsala University June 1 2022 Phase 1

Chemical lnformation & Solubility

Molecular Weight 303.31 Formula

C12H21N3O6
CAS No. 56491-86-2 SDF --
Smiles OC(=O)CN1CCN(CCN(CC1)CC(O)=O)CC(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 61 mg/mL ( (201.11 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL

Ethanol : 2 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy NOTA | NOTA supplier | purchase NOTA | NOTA cost | NOTA manufacturer | order NOTA | NOTA distributor