Home Proteases HCV Protease inhibitor Ombitasvir (ABT-267) For research use only.

Ombitasvir (ABT-267)

Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.

Ombitasvir (ABT-267) Chemical Structure

Ombitasvir (ABT-267) Chemical Structure

CAS: 1258226-87-7

Selleck's Ombitasvir (ABT-267) has been cited by 3 publications

Purity & Quality Control

Batch: S540301 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.77%
99.77

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Biological Activity

Description Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.
Targets
NS5A [1]
In vitro
In vitro Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC50s) of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a. Ombitasvir has EC50s of 14.1 and 5.0 pM against genotype 1a-H77 and 1b-Con1 subgenomic replicons, respectively[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02581020 Completed Hepatitis C Virus AbbVie January 14 2016 --
NCT02534870 Completed Healthy Volunteer AbbVie September 2015 Phase 1
NCT02734173 Completed Hepatitis C Ottawa Hospital Research Institute|AbbVie July 2015 Phase 4
NCT01911845 Completed Chronic Hepatitis C Infection|Chronic Hepatitis C AbbVie April 2013 Phase 2

Chemical lnformation & Solubility

Molecular Weight 894.11 Formula

C50H67N7O8
CAS No. 1258226-87-7 SDF --
Smiles CC(C)C(C(=O)N1CCCC1C(=O)NC2=CC=C(C=C2)C3CCC(N3C4=CC=C(C=C4)C(C)(C)C)C5=CC=C(C=C5)NC(=O)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (111.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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