Home Metabolism MAO inhibitor Pargyline hydrochloride For research use only.

Pargyline hydrochloride

Synonyms: Pargylamine hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

Pargyline hydrochloride Chemical Structure

Pargyline hydrochloride Chemical Structure

CAS: 306-07-0

Selleck's Pargyline hydrochloride has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.
Targets
MAO-B [1]
(Cell-free assay)		 MAO-A [1]
(Cell-free assay)
0.5 μM(Ki) 13 μM(Ki)
In vitro
In vitro Pargyline, an MAO inhibitor, prevents the activity of lysine-specific demethylase 1 (LSD1) and is excessively expressed in breast cancer. The proliferation of cells exposed to pargyline decreases in a dose- and time-dependent manner. The treatment of 2 mM pargyline exhibits an increase of the cell proportion at the G1 phase, while the major decrease of the cell proportion is at the S phase. pargyline induces an increase in the cleaved PARP expression[2].
Cell Research Cell lines T47D cells
Concentrations 0.5, 1, 1.5 and 2 mM
Incubation Time 24, 48, 72, 96 and 120 h
Method --
In Vivo
In vivo Chronic treatment (14 days) with pargyline (10 mg/kg) markedly down-regulate the density of NAIBS (non-adrenoceptor idazoxan binding sites) in the rat brain[3].
Animal Research Animal Models Sprague-Dawley rats
Dosages 10 mg/kg
Administration i.p.

Chemical lnformation & Solubility

Molecular Weight 195.69 Formula

C11H13N.HCl
CAS No. 306-07-0 SDF Download Pargyline hydrochloride SDF
Smiles CN(CC#C)CC1=CC=CC=C1.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 39 mg/mL ( (199.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 39 mg/mL

Ethanol : 39 mg/mL


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In vivo
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