Pembrolizumab (anti-PD-1)

Synonyms: MK-3475, lambrolizumab

Catalog No.A2005 Purity: 99%

Pembrolizumab (anti-PD-1) is a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.

Pembrolizumab (anti-PD-1) Chemical Structure

Click to purchase the isotype control of Pembrolizumab (anti-PD-1)

Selleck's Pembrolizumab (anti-PD-1) has been cited by 48 publications

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 15.94mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective PD-1/PD-L1 Inhibitors

Biological Activity

Description

Features

Human IgG4

Targets

PD-1 ^[1]
(Cell-free assay)

In Vitro
In vitro	The level of LDH and apoptosis are significantly higher in those treated with dexamethasone plus PD1 inhibitor pembrolizumab than other groups.^[1]
Cell Research:	Cancer cells were incubated with dexamethasone for 48 h followed by co-cultured with PBMCs with effector/target ratio of 10:1 and the addition of PD1 inhibitor (pembrolizumab; 5 μg/mL) for another 48 h. LDH level was detected.

In Vitro

In vitro

The level of LDH and apoptosis are significantly higher in those treated with dexamethasone plus PD1 inhibitor pembrolizumab than other groups.^[1]

Cell Research:

Cancer cells were incubated with dexamethasone for 48 h followed by co-cultured with PBMCs with effector/target ratio of 10:1 and the addition of PD1 inhibitor (pembrolizumab; 5 μg/mL) for another 48 h. LDH level was detected.

In Vivo
In vivo	Pembrolizumab and dexamethasone synergistically suppress tumor growth of pancreatic cancer in vivo.^[1]
Animal Research	Animal Models: Immune reconstituted NOD/SCID mice model Dosages: 5 mg/kg Administration: i.v. Reference: [1]

References
[1] Xiang Z, et al. Oncogene. 2021 Aug;40(31):5002-5012.

References

[1] Xiang Z, et al. Oncogene. 2021 Aug;40(31):5002-5012.

Product Details

CAS No.	1374853-91-4
Isotype	Human IgG4
Source	CHO cells
Formulation	PBS buffer, pH 7.2
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.