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Pemirolast potassium

Name: Pemirolast potassium
Brand: Selleck Chemicals
SKU: S4008
Rating: 5 (2 reviews)

Synonyms: BMY26517

Catalog No.S4008 Purity: 99.97%

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Pemirolast potassium Chemical Structure

CAS: 100299-08-9

Selleck's Pemirolast potassium has been cited by 2 publications

Purity & Quality Control

Batch: S400801 Water] 53 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.97%

99.97

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Biological Activity

Description

Pemirolast potassium (BMY26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

Targets

Histamine H1 receptor ^[2]

In vitro
In vitro	Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma. ^[1] Pemirolast potassium (BMY 26517) inhibits chemical mediator release from tissue mast cells and is also shown to inhibit the release of peptides including substance P, ^[2] neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. ^[3] Pemirolast potassium is used for the treatment of allergic conjunctivitis and prophylaxis for pulmonary hypersensitivity reactions to drugs such as paclitaxel. ^[4]

In Vivo
In vivo	Pemirolast potassium (BMY 26517) reduces kaolin intake by inhibition of substance P release in rats. ^[2] Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. ^[3]

References

[4] Abelson MB, et al. J Ocul Pharmacol Ther, 2002, 18(5), 475-488.

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Chemical lnformation & Solubility

Molecular Weight	266.3	Formula	C₁₀H₇N₆O.K
CAS No.	100299-08-9	SDF	Download Pemirolast potassium SDF
Smiles	CC1=CC=CN2C1=NC=C(C2=O)C3=NN=N[N-]3.[K+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 53 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Handling Instructions

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