Home Neuronal Signaling GABA Receptor antagonist Pentylenetetrazol For research use only.

Pentylenetetrazol

Synonyms: Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ

Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

Pentylenetetrazol Chemical Structure

Pentylenetetrazol Chemical Structure

CAS: 54-95-5

Selleck's Pentylenetetrazol has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.69%
99.69

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Biological Activity

Description Pentylenetetrazol (Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ) displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
Targets
GABA receptor [1]
In Vivo
In vivo Administration of PTZ (45 mg/kg i.p.) induces clonic convulsions in almost all of the animals after a single injection, typically within 3 min. However, 11% of animals need a second injection to cause clonus. Each rat shows jerking or myoclonus followed by clonus or tonic-clonic convulsions. PTZ injection results in significant changes in GABAA receptor subunit mRNAs. A single PTZ-induced convulsion is associated with rapid changes in GABAA receptors[1].
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 45 mg/kg
Administration i.p.

Chemical lnformation & Solubility

Molecular Weight 138.17 Formula

C6H10N4
CAS No. 54-95-5 SDF Download Pentylenetetrazol SDF
Smiles C1CCC2=NN=NN2CC1
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( (202.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL


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In vivo
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