Home Microbiology Neuraminidase inhibitor - Influenza Virus inhibitor Peramivir Trihydrate For research use only.

Peramivir Trihydrate

Synonyms: BCX-1812, RWJ-270201, S-021812

Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

Peramivir Trihydrate Chemical Structure

Peramivir Trihydrate Chemical Structure

CAS: 1041434-82-5

Selleck's Peramivir Trihydrate has been cited by 2 Publications

1 Customer Review

Purity & Quality Control

Batch: S271601 5%TFA] 3 mg/mL] false] DMSO] 0.2 mg/mL] false] Water] Insoluble] false Purity: 100%
100

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Biological Activity

Description Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.
In Vivo
In vivo Peramivir protects mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets. [1] Peramivir combined with Oseltamivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. [2] Peramivir (30 mg/kg) is effective in promoting the survival of mice infected with systemically replicating H5N1 virus. [3] Peramivir is 30% protective against H1N1 virus in mice at 0.5 mg/kg/d, but ineffective at lower doses when used as monotherapy. Peramivir combined with favipiravir increases the numbers of survivors by 10-50% when the 0.025 mg/kg/d, 0.05 mg/kg/d, and 0.1 mg/kg/d doses of Peramivir are combined with 20 mg/kg/d Favipiravir and when all doses of Peramivir are combined with 40 mg/kg/d Favipiravir. Peramivir combined with favipiravir results in an increase in lifespan, improved body weight and significant reductions in lung hemorrhage score and lung weight in H1N1 infected mice. [4] Peramivir (1 mg/kg/d) combined with Rimantadine (5 mg/kg/d and 10 mg/kg/d) produces weight losses of 1.69 and 0.69, respectively, whereas the combination of 3.0 mg/kg/d Peramivir with 10 and 30 mg/kg/d Rimantadine does not show any weight loss in sub-lethal influenza A (H3N2) virus mouse model. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02635724 Completed Influenza BioCryst Pharmaceuticals December 2015 Phase 3
NCT02369159 Completed Influenza BioCryst Pharmaceuticals March 11 2015 Phase 3
NCT01224795 Terminated Influenza BioCryst Pharmaceuticals|Department of Health and Human Services October 2010 Phase 3
NCT01146353 Withdrawn Influenza|Renal Failure Midwestern University|Northwestern University|BioCryst Pharmaceuticals February 2010 --
NCT01063933 Withdrawn Influenza National Institute of Allergy and Infectious Diseases (NIAID) Phase 1|Phase 2

Chemical lnformation & Solubility

Molecular Weight 382.45 Formula

C15H28N4O4.3H2O
CAS No. 1041434-82-5 SDF Download Peramivir Trihydrate SDF
Smiles CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O
Storage (From the date of receipt)

In vitro
Batch:

5%TFA : 3 mg/mL

DMSO : 0.2 mg/mL ( (0.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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