Home Cell Cycle CDK inhibitor PF-07220060 (CDK4/6-IN-6) For research use only.

PF-07220060 (CDK4/6-IN-6)

Synonyms: CDK4/6-IN-6

PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

PF-07220060 (CDK4/6-IN-6) Chemical Structure

PF-07220060 (CDK4/6-IN-6) Chemical Structure

CAS: 2380321-51-5

Purity & Quality Control

Batch: E149501 DMSO] 93 mg/mL] false] Ethanol] 23 mg/mL] false] Water] Insoluble] false Purity: 99.04%
99.04

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Biological Activity

Description PF-07220060 (CDK4/6-IN-6) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
Targets
CDK4/CyclinD1 [1] CDK6/cyclin D3 [1]
0.6 nM(Ki) 13.9 nM(Ki)

Chemical lnformation & Solubility

Molecular Weight 463.93 Formula

C22H27ClFN5O3
CAS No. 2380321-51-5 SDF Download PF-07220060 (CDK4/6-IN-6) SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 93 mg/mL ( (200.46 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 23 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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