Home GPCR & G Protein 5-HT Receptor inhibitor Pimavanserin tartrate For research use only.

Pimavanserin tartrate

Synonyms: ACP-103

Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.

Pimavanserin tartrate Chemical Structure

Pimavanserin tartrate Chemical Structure

CAS: 706782-28-7

Selleck's Pimavanserin tartrate has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.86%
99.86

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Biological Activity

Description Pimavanserin tartrate(ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.
Targets
5-HT2A [1]
(cell-based assay)
8.7(pIC50)
In Vivo
In vivo

In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. [1] In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements. [2]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 3 mg/kg
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05796167 Not yet recruiting Parkinson Disease State University of New York - Downstate Medical Center|ACADIA Pharmaceuticals Inc. January 9 2024 Early Phase 1
NCT05555615 Recruiting Irritability Associated With Autism Spectrum Disorder ACADIA Pharmaceuticals Inc. November 2 2022 Phase 2|Phase 3
NCT04794413 Completed Tourette Syndrome|Tardive Dyskinesia Joseph Jankovic|Andrew Billnitzer MD|Baylor College of Medicine November 12 2018 Early Phase 1
NCT03121586 Recruiting Schizophrenia ACADIA Pharmaceuticals Inc. January 2017 Phase 3
NCT00087542 Completed Hallucinations|Psychoses|Parkinson''s Disease ACADIA Pharmaceuticals Inc. March 2004 Phase 2

Chemical lnformation & Solubility

Molecular Weight 1005.2 Formula

C50H68F2N6O4.C4H6O6
CAS No. 706782-28-7 SDF Download Pimavanserin tartrate SDF
Smiles CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.C(C(C(=O)O)O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (99.48 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 25 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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