Home Neuronal Signaling GABA Receptor agonist - GluR agonist Piracetam For research use only.

Piracetam

Synonyms: UCB 6215

Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.

Piracetam Chemical Structure

Piracetam Chemical Structure

CAS: 7491-74-9

Purity & Quality Control

Batch: S307001 DMSO] 72 mg/mL] false] Water] 72 mg/mL] false] Ethanol] Insoluble] false Purity: 100%
100

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Biological Activity

Description Piracetam (UCB 6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
Targets
AMPA receptor [1]
In vitro
In vitro Piracetam is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. Preincubation of piracetam, at a piracetam/peptide ratio of 960, during 20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescent probes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced by the peptide in a dose-dependent fashion (piracetam/peptide ratios from 9.6 to 960). [1] Piracetam (< 1.0 mM) preincubated with brain membranes enhances membrane fluidity in aged mice, rats and humans, as indicated by decreased anisotropy of the membrane-bound fluorescence probe 1,6-diphenyl-1,3,5-hexatriene (DPH). [2]
In Vivo
In vivo Piracetam (300 mg/kg once daily) significantly increases membrane fluidity in some brain regions of young and aged rats, but has no measurable effect on membrane fluidity in the young rats. [2] Piracetam (300 mg/kg daily for 6 weeks) improves active avoidance learning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in the aged rats. Piracetam (300 mg/kg daily for 6 weeks) also improves NMDA receptor density in the hippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to a lesser extent in the hippocampus of rats. [3] Piracetam (500 mg/kg p.o. for 14 days) elevates N-methyl-D-aspartate (NMDA) receptor density by about 20% and normalizes the enhanced affinity of L-glutamate for the NMDA receptor in aged mice. [4] Piracetam-treated withdrawn rats has higher the number of synapses than that observed in nonpiracetam-treated and alcohol-fed animals by up to 20%, the mechanisms leading to the synaptic reorganization took place at the mossy fiber level. [5]
Animal Research Animal Models male Wistar rats
Dosages 300 mg/kg
Administration Orally
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05918341 Not yet recruiting Drug Adherence Marker The Netherlands Cancer Institute July 3 2023 Phase 4
NCT00567060 Completed Memory Disorders UCB Pharma May 2000 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 142.16 Formula

C6H10N2O2
CAS No. 7491-74-9 SDF Download Piracetam SDF
Smiles C1CC(=O)N(C1)CC(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 72 mg/mL ( (506.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 72 mg/mL

Ethanol : Insoluble


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In vivo
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