Home Microbiology Hydrotropic Agents inhibitor - Anti-infection chemical Povidone iodine For research use only.

Povidone iodine

Synonyms: Betadine, PVP iodine, PVP-I, Isodine

Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. Povidone iodine displays excellent antibacterial activity against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. Povidone iodine is used as a topical antiseptic in surgery and for skin and mucous membrane infections, as well as as an aerosol.

Povidone iodine Chemical Structure

Povidone iodine Chemical Structure

CAS: 25655-41-8

Purity & Quality Control

Batch: S467801 DMSO] 28 mg/mL] false] Water] 28 mg/mL] false] Ethanol] 28 mg/mL] false Purity: 99%
99

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Biological Activity

Description Povidone iodine (Betadine, PVP iodine, PVP-I, Isodine) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. Povidone iodine displays excellent antibacterial activity against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. Povidone iodine is used as a topical antiseptic in surgery and for skin and mucous membrane infections, as well as as an aerosol.
In vitro
In vitro

Exposure to PVP-I, of which concentrations are even lower than those used clinically, causes toxicity in epithelial cells[2].
Cell Research Cell lines HeLa cells
Concentrations 0.01-1000 μM
Incubation Time 1 or 2 days
Method

One day after seeding, wells are exposed to PVP-I (0.01 to 1000 μM), which has been diluted with DMEM containing 10% FBS. Plates are further cultured for 1 or 2 days at 37℃ in a 5% CO2 incubator. The cell incubation time of 1 or 2 days is determined based on data regarding the onset time of iododerma and nephropathy pathogenesis.
In Vivo
In vivo

Povidone-iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds, using the antiseptic properties of iodine. A study investigating its use in defective tissue in neural structures reveals that Myelin changes are absent or minimal in all cases of the control group but are present as markedly increased myelin degeneration in nearly all cases in the PVP-I group. Axonal degeneration and hypoxic neuronal damage are absent in the control group, whereas they are marked in half of the PVP-I group. No statistically significant differences are established in Schwann cell proliferation, venous congestion, and lymphocytic proliferation between the two groups[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05745467 Withdrawn SARS-CoV-2 Acute Respiratory Disease University of Iowa|3M July 3 2024 Phase 4
NCT05696132 Not yet recruiting MRSA Nantes University Hospital February 2023 Phase 2
NCT05704959 Active not recruiting HEALTHY INDIVIDUALS Hasan Kalyoncu University March 15 2022 Not Applicable
NCT05077592 Unknown status Surgical Site Infection|Surgical Wound Infection Ain Shams University September 18 2021 Phase 4
NCT04658355 Unknown status Vaginal Flora Imbalance University of Arizona December 15 2020 Not Applicable

Chemical lnformation & Solubility

Molecular Weight Formula

(C6H9NO)x.xI2
CAS No. 25655-41-8 SDF Download Povidone iodine SDF
Smiles C=CN1CCCC1=O.II
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( ； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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