Home Neuronal Signaling Histamine Receptor antagonist Promethazine For research use only.

Promethazine

Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.

Promethazine Chemical Structure

Promethazine Chemical Structure

CAS: 60-87-7

Purity & Quality Control

Batch: S519601 DMSO] 29 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.61%
99.61

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Biological Activity

Description Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
Targets
histamine H1 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Not yet recruiting Post-operative Nausea and Vomiting Milton S. Hershey Medical Center January 2024 Phase 2
NCT04805073 Recruiting Pruritus|Pregnancy Related University of Florida August 9 2021 Phase 4
NCT03539562 Completed Labor Pain|Early Labor University of California San Francisco September 27 2017 --
NCT02465866 Completed Healthy Charleston Laboratories Inc November 2014 Phase 1
NCT01644838 Completed Labor Pain Mashhad University of Medical Sciences August 2010 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 284.42 Formula

C17H20N2S
CAS No. 60-87-7 SDF --
Smiles CC(CN1C2=CC=CC=C2SC3=CC=CC=C13)N(C)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 29 mg/mL ( (101.96 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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