Home Transmembrane Transporters Sodium Channel antagonist Proparacaine HCl For research use only.

Proparacaine HCl

Synonyms: Proxymetacaine Hydrochloride

Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Proparacaine HCl Chemical Structure

Proparacaine HCl Chemical Structure

CAS: 5875-06-9

Purity & Quality Control

Batch: S182801 Water] 66 mg/mL] false] DMSO] 12 mg/mL] false] Ethanol] Insoluble] false Purity: 99.60%
99.60

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Biological Activity

Description Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
Targets
Voltage-gated sodium channel [1]
3.4 mM(ED50)
In vitro
In vitro

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]
In Vivo
In vivo

Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]
Animal Research Animal Models Male Sprague–Dawley rats
Dosages ~10 μmol/kg
Administration Intrathecally

Chemical lnformation & Solubility

Molecular Weight 330.85 Formula

C16H26N2O3.HCl
CAS No. 5875-06-9 SDF Download Proparacaine HCl SDF
Smiles CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 66 mg/mL

DMSO : 12 mg/mL ( (36.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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