Home Transmembrane Transporters Sodium Channel inhibitor Quinidine hemisulfate hydrate For research use only.

Quinidine hemisulfate hydrate

Synonyms: Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

Quinidine hemisulfate hydrate Chemical Structure

Quinidine hemisulfate hydrate Chemical Structure

CAS: 6591-63-5

Selleck's Quinidine hemisulfate hydrate has been cited by 2 publications

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Description Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Targets
Sodium channel [1]
In vitro
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates[1].
Cell Research Cell lines HMM cell lines HIB, and TRA
Concentrations 2.5, 5, 10, 25 μM
Incubation Time 4 days
Method

Cells were cultured on T25 cm2 flasks in the presence of different concentrations of quinidine for 4 days. Bromodeoxyuridine was added for 8.5 hours, after which cells were trypsinized and spun down for 10 minutes at 1500 revolutions per minute. Cells were washed twice in 1% BSA/phosphate-buffered saline (PBS) and fixed with 70% ethanol on ice. DNA was denatured by 2N HCl/Triton X100 at room temperature for 30 minutes and sodium tetraborate was added to neutralize the pH level. After centrifugation, cells were resuspended in 1% BSA/0.5% Tween 20/PBS and the cell concentration was adjusted to 1 x 106 cells per test.
In Vivo
In vivo

Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo[2].
Animal Research Animal Models Lewis rats
Dosages 80 mg/kg
Administration p.o.

Chemical lnformation & Solubility

Molecular Weight 391.47 Formula

C20H24N2O2.1/2H2SO4.H2O
CAS No. 6591-63-5 SDF Download Quinidine hemisulfate hydrate SDF
Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
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