Home Immunology & Inflammation β-lactamase inhibitor Relebactam For research use only.

Relebactam

Synonyms: MK-7655

Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases.

Relebactam Chemical Structure

Relebactam Chemical Structure

CAS: 1174018-99-5

Purity & Quality Control

Batch: S007401 DMSO] 70 mg/mL] false] Water] 70 mg/mL] false] Ethanol] Insoluble] false Purity: 99.75%
99.75

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Biological Activity

Description Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases.
Targets
β-lactamase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05561764 Recruiting Cystic Fibrosis|Pneumonia Bacterial Hartford Hospital|Merck Sharp & Dohme LLC|Q2 Solutions|Connecticut Children''s Medical Center|St. Christopher''s Hospital for Children|University of Texas Southwestern Medical Center|University of Pittsburgh Medical Center|Indiana University Health Methodist Hospital|James Whitcomb Riley Hospital for Children January 3 2023 Phase 4
NCT05146154 Enrolling by invitation Obesity|Critical Illness University of Illinois at Chicago|Merck Sharp & Dohme LLC January 1 2023 Phase 4
NCT05285046 Enrolling by invitation Bacterial Infections|Antibiotic Resistant Infection D''Or Institute for Research and Education April 1 2022 --
NCT04493151 Completed Sepsis Joseph L. Kuti PharmD|Merck Sharp & Dohme LLC|Hartford Hospital January 1 2021 Phase 1
NCT04147221 Completed Sepsis Hartford Hospital|Merck Sharp & Dohme LLC February 10 2020 Phase 1
NCT03969901 Recruiting Suspected or Documented Gram-negative Bacterial Infection Merck Sharp & Dohme LLC October 8 2019 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 348.38 Formula

C12H20N4O6S
CAS No. 1174018-99-5 SDF --
Smiles C1CC(N2CC1N(C2=O)OS(=O)(=O)O)C(=O)NC3CCNCC3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 70 mg/mL ( (200.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 70 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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